At the end of the 4th decade of life in men having prostate hyperplasia mikrofokusy stromal cells, which gradually grow and merge together to form a "benign tumor" what is avodart. Slowly increasing the size, it begins to squeeze and squeeze the urethra anteriorly, and the true tissue prostate outwards.
Fibrous connective tissue formed the boundary between the real and proliferating hyperplastic prostate tissue - the so-called surgical capsule. Where prostatic hyperplasia significant amount reaches it almost completely replace the true prostate tissue, leaving only a strip of impaction on its periphery gland.
Epidemiological studies have shown that prostate hyperplasia - one of the most common diseases of male elderly. At the age of about 50 years, it occurs in 50% of men older than 60 - 60%, over 70 years of prostate adenoma is diagnosed in 70-80% of cases.
Etiology and pathogenesis. Among the risk factors for the disease are significantly proven advanced age and the presence of functioning of the testes. Their removal by virtue of those or other reasons leads to underdevelopment of the prostate gland, or reverse the development of hyperplastic prostate.
In the pathogenesis of benign prostatic hyperplasia proved the most important role of strengthening the androgen metabolism in the cells of the prostate gland. Increased activity of 5-a-reductase in the epithelium of prostatic glands leads to intensification of intracellular pathways in the metabolism of testosterone 5-a-dihydrotestosterone. The latter, acting through the androgen receptor and the DNA of the nuclei of the prostate cells, activation operation determines tissue growth factors (fibroblast, insulin-like, transforming And they, in turn, stimulate the proliferation of prostate stromal cells, leading to the development of its hyperplasia.
What is the basis of increasing the activity of 5-a-reductase inhibitor, significantly is not known. But, believe that this is due to increased estrogen exposure, the relative content of which at least male aging increases.
Of great importance in the development of prostatic hyperplasia recently paid a genetic and hereditary factors. Their role in the pathogenesis of the disease, especially in patients relatively young age, has been studied extensively.
Interestingly, in terms of preventing the development of prostatic hyperplasia, is the value of the power of the male population. Beneficial effect of soy and soy products, vitamins E and A, lycopene contained in tomatoes, beta-sitosterol, pumpkin and zucchini, green tea proved significantly lower incidence of prostatic hyperplasia in South-East Asia as compared to Europe and the USA.
The natural development of prostatic hyperplasia. The complications of the disease. 80-90% of men have prostate hyperplasia exposed progressive growth, and in only 10-20% of it remains in a stable state. The progress of the disease gradually leads to symptoms. Their appearance is due both to the development of the pathological process and the addition of various complications.
One of the first bladder outlet obstruction occurs, ie. E. Below the bladder obstruction. The growth of hyperplastic prostate tissue leads to mechanical compression of the urethra - mechanical component of bladder outlet obstruction. In addition, development of hyperplasia and increases the number of functional activity A1a adrenoceptor prostate, bladder neck and prostatic urethra.
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